The Detective: Kenneth Branagh as Hercule Poirot

The Fugitive: Johnny Depp as Edward Ratchett

The Tourist: Michelle Pfeiffer as Caroline Hubbard

Manuel Garcia-Rulfo as Biniamino Marquez, Daisy Ridley as Mary Debenham, and Leslie Odom Jr. as Doctor Arbuthnot

The Physician: Leslie Odom Jr. as Doctor Arbuthnot

The Governess: Daisy Ridley as Mary Debenham

The Businessman: Manuel Garcia-Rulfo as Biniamino Marquez

Olivia Colman as Hildegarde Schmidt and Judi Dench as Princess Dragomiroff

The Aristocrat: Judi Dench as Princess Dragomiroff

The Maid: Olivia Colman as Hildegarde Schmidt

The Missionary:  Penelope Cruz as Pilar Estravados

The Dancer: Sergei Polunin as Count Andrenyi

Josh Gad as Hector MacQueen and Johnny Depp as Edward Ratchett

The Assistant: Josh Gad as Hector MacQueen

The Valet: Derek Jacobi as Masterman

The Scholar: Willem Dafoe as Gerhard Hardman

The Addict: Lucy Boynton as Countess Andrenyi

The Attendant: Marwan Kenzari as Pierre Michel

The Director: Tom Bateman as Bouc